The district is part of the Karamoja sub-region, home to an estimated 1.2 million Karimojong, according to the 2002 national census. The sub-region consists of the following districts: (a) Abim District (b) Amudat District (c) Kaabong District (d) Kotido District (e) Moroto District (f) Nakapiripirit District and (g) Napak District.
In 1991, the national population census estimated the district population at about 62,340. The national census in 2002 estimated the population of the district at about 129,100. The annual population growth rate in Kotido District, between 2002 and 2012, has been calculated at 6.39%. It is estimated that in 2012, the population of Kotido District was approximately 236,900